Reformulating existing pharmaceutical molecules in microgravity
Zero Gravity Works (ZGW), in collaboration with Segula Technologies and the Department of Drug Sciences at the University of Pavia, is developing a reusable autonomous orbital module to crystallize and process high-value pharmaceutical molecules in microgravity.By exploiting microgravity, ZGW unlocks improved formulations thanks to novel solid-state forms that cannot be achieved on Earth.
Zero Gravity Works S.r.l. - VAT IT13305290010
Why microgravity matters
On Earth, gravity introduces convection and sedimentation during crystallization. In microgravity, diffusion dominates, enabling more uniform crystal growth and access to solid‑state forms that may be difficult or impossible to reliably obtain on Earth.
For selected molecules this may enable:
- discovery of new polymorphs
- improved solubility and bioavailability
- greater stability and manufacturability
- predictable particle morphology
- new, defensible solid‑state IP
Why now
Commercial space infrastructure has transformed what is possible. Reusable capsules, commercial launch services and rapid re‑entry capabilities now allow routine orbital missions.
Companies such as Varda Space Industries have demonstrated the feasibility of orbital pharmaceutical manufacturing, while logistics providers, such as Space Cargo Unlimited, show that access to space is becoming operationally viable for industrial partners.
ZGW is building a reusable European platform designed specifically for pharmaceutical collaboration.
Who we are looking for
We are currently engaging with pharmaceutical companies, biotech firms, API manufacturers, CDMOs and simulation technology providers interested in next‑generation formulation strategies.We are particularly interested in organizations active in:
- late‑stage or marketed small molecules
- lifecycle extension strategies
- polymorph or solubility challenges
- computational chemistry and crystal growth simulation.Early partners can co‑design experiments, access microgravity‑processed batches and evaluate new solid‑state opportunities.
Let's Explore the Potential of Your Molecule
If you are evaluating reformulation strategies, polymorph screening or lifecycle extension opportunities, we would be pleased to discuss whether microgravity processing could be relevant to your portfolio.Please fill the form or send an email to [email protected].
Thank you!
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